| Southampton FC v Chelsea FC 30/10/2016 | £17.00 | |
| Southampton FC v Internazionale/Inter Milan 03/11/2016 | £2.50 | |
| Southampton FC v Internazionale/Inter Milan 03/11/2016 | £6.00 | |
| Southampton FC v Liverpool FC 19/11/2016 | £6.50 | |
| Southampton FC v Everton FC 27/11/2016 | £6.50 | |
| Arsenal FC v Southampton FC 30/11/2016 | £6.00 | |
| Crystal Palace FC v Southampton FC 03/12/2016 | £6.50 | |
| Southampton FC v Hapoel Beer - Sheva 08/12/2016 | £5.50 | |
| Southampton FC v Hapoel Beer - Sheva 08/12/2016 | £6.50 | |
| Southampton FC v Tottenham Hotspur FC 28/12/2016 | £5.50 | |
| Southampton FC v Tottenham Hotspur FC 28/12/2016 | £6.50 | |
| Southampton FC v West Bromwich Albion FC 31/12/2016 | £6.50 |