| Southampton FC v Chelsea FC 02/04/2005 | £7.00 | |
| Luton Town FC v Southampton FC 09/08/2005 | £6.00 | |
| Sheffield Wednesday FC v Southampton FC 13/08/2005 | £2.00 | |
| Sheffield Wednesday FC v Southampton FC 13/08/2005 | £3.00 | |
| Southampton FC v Reading FC 28/09/2005 | £7.00 | |
| Southampton FC v Brighton & Hove Albion FC 02/01/2006 | £5.00 | |
| Southampton FC v MK Dons (Milton Keynes Dons) 07/01/2006 | £3.70 | |
| Queens Park Rangers FC v Southampton FC 14/01/2006 | £4.00 | |
| Leicester City FC v Southampton FC 28/01/2006 | £4.80 | |
| Reading FC v Southampton FC 10/02/2006 | £6.50 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.00 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.50 |