| Southampton FC v Sunderland FC 15/10/1960 | View match | |
| Southampton FC v Newport County 17/10/1960 | £7.00 | |
| Plymouth Argyle FC v Southampton FC 22/10/1960 | View match | |
| Southampton FC v Newport County 26/10/1960 | View match | |
| Southampton FC v Norwich City FC 29/10/1960 | View match | |
| Colchester United FC v Southampton FC 31/10/1960 | View match | |
| Charlton Athletic FC v Southampton FC 05/11/1960 | View match | |
| Southampton FC v Sheffield United FC 12/11/1960 | View match | |
| Liverpool FC v Southampton FC 16/11/1960 | View match | |
| Stoke City FC v Southampton FC 19/11/1960 | View match | |
| Southampton FC v Swansea Town 26/11/1960 | View match | |
| Luton Town FC v Southampton FC 03/12/1960 | View match |