| Tottenham Hotspur FC v Brighton & Hove Albion FC 16/04/2022 | £8.50 | |
| Watford FC v Brentford FC 16/04/2022 | £7.50 | |
| Manchester City FC v Liverpool FC 16/04/2022 | £7.50 | |
| Heart Of Midlothian (Hearts) v Hibernian FC 16/04/2022 | £7.50 | |
| Celtic (Glasgow) FC v Rangers (Glasgow) FC 17/04/2022 | £7.50 | |
| West Ham United FC v Burnley FC 17/04/2022 | £7.50 | |
| Tranmere Rovers FC v Exeter City FC 18/04/2022 | £7.50 | |
| Cardiff City FC v Luton Town FC 18/04/2022 | £8.00 | |
| Nottingham Forest FC v West Bromwich Albion FC 18/04/2022 | £7.50 | |
| AFC Wimbledon FC v Wycombe Wanderers FC 18/04/2022 | £7.50 | |
| Cambridge United FC v Charlton Athletic FC 19/04/2022 | £7.50 | |
| Sheffield Wednesday FC v Crewe Alexandra FC 19/04/2022 | £7.50 |