| Boness United v Johnstone 25/03/1922 | View match | |
| Hamilton Academicals v Dundee 25/03/1922 | View match | |
| Airdrieonians (Old) v Third Lanark 25/03/1922 | View match | |
| Dunfermline Athletic v Bathgate 25/03/1922 | View match | |
| St Mirren FC v Motherwell FC 25/03/1922 | View match | |
| Lochgelly United v Cowdenbeath FC 25/03/1922 | View match | |
| Clackmannan v St Bernard`s 25/03/1922 | View match | |
| Queens Park FC v Kilmarnock FC 25/03/1922 | View match | |
| Aberdare Athletic v Swindon Town FC 25/03/1922 | View match | |
| Stalybridge Celtic v Ashington 25/03/1922 | View match | |
| Durham City v Rochdale FC 25/03/1922 | View match | |
| Dumbarton v Albion Rovers FC 25/03/1922 | View match |