| Southport v Tranmere Rovers FC 10/12/1921 | View match | |
| Liverpool FC v Aston Villa FC 10/12/1921 | View match | |
| Wigan Borough v Rochdale FC 10/12/1921 | View match | |
| Dumbarton v Falkirk FC 10/12/1921 | View match | |
| Broxburn United v Armadale 10/12/1921 | View match | |
| Hibernian FC v Albion Rovers FC 10/12/1921 | View match | |
| Forfar Athletic FC v Dunfermline Athletic 10/12/1921 | View match | |
| Aberdeen FC v St Mirren FC 10/12/1921 | View match | |
| Clyde v Hamilton Academicals 10/12/1921 | View match | |
| Rangers (Glasgow) FC v Third Lanark 10/12/1921 | View match | |
| East Stirlingshire FC v Stenhousemuir FC 10/12/1921 | View match | |
| Morton FC v Kilmarnock FC 10/12/1921 | View match |