| Oldham Athletic FC v Birmingham 03/12/1921 | View match | |
| Watford FC v Queens Park Rangers FC 03/12/1921 | View match | |
| Vale Of Leven v Bathgate 03/12/1921 | View match | |
| Albion Rovers FC v Ayr United FC 03/12/1921 | View match | |
| Partick Thistle FC v Motherwell FC 03/12/1921 | View match | |
| Hamilton Academicals v Raith Rovers FC 03/12/1921 | View match | |
| Dundee v Clyde 03/12/1921 | View match | |
| Dunfermline Athletic v Lochgelly United 03/12/1921 | View match | |
| Clackmannan v Boness United 03/12/1921 | View match | |
| St Mirren FC v Dumbarton 03/12/1921 | View match | |
| Armadale v Alloa Athletic FC 03/12/1921 | View match | |
| Third Lanark v Hibernian FC 03/12/1921 | View match |