| Falkirk FC v Clydebank FC (Old) 08/10/1921 | View match | |
| Boness United v Armadale 08/10/1921 | View match | |
| Kings Park v St Johnstone FC 08/10/1921 | View match | |
| Rangers (Glasgow) FC v Heart Of Midlothian (Hearts) 08/10/1921 | View match | |
| Broxburn United v Cowdenbeath FC 08/10/1921 | View match | |
| Hibernian FC v Morton FC 08/10/1921 | View match | |
| Forfar Athletic FC v East Fife FC 08/10/1921 | View match | |
| Clyde v Queens Park FC 08/10/1921 | View match | |
| Wigan Borough v Walsall FC 08/10/1921 | View match | |
| Dumbarton v Airdrieonians (Old) 08/10/1921 | View match | |
| Nelson v Accrington Stanley (1891) 15/10/1921 | View match | |
| Ashington v Barrow 15/10/1921 | View match |