| Dundee v Motherwell FC 03/10/1921 | View match | |
| Celtic (Glasgow) FC v St Mirren FC 04/10/1921 | View match | |
| Motherwell FC v Clyde 04/10/1921 | View match | |
| Third Lanark v Dumbarton 04/10/1921 | View match | |
| Armadale v Johnstone 05/10/1921 | View match | |
| Vale Of Leven v Dunfermline Athletic 05/10/1921 | View match | |
| Fulham (Res) v Crystal Palace (Res) 06/10/1921 | View match | |
| Notts County FC v Barnsley FC 06/10/1921 | View match | |
| Notts County FC v Blackpool FC 08/10/1921 | View match | |
| Barrow v Ashington 08/10/1921 | View match | |
| Grimsby Town FC v Hartlepool United 08/10/1921 | View match | |
| Bury FC v Port Vale FC 08/10/1921 | View match |