| Wigan Borough v Nelson 03/09/1921 | View match | |
| Alloa Athletic FC v Bathgate 03/09/1921 | View match | |
| Aberdare Athletic v Swansea Town 05/09/1921 | View match | |
| Albion Rovers FC v Raith Rovers FC 05/09/1921 | View match | |
| The Wednesday v Derby County FC 05/09/1921 | View match | |
| Stoke v South Shields AFC 05/09/1921 | View match | |
| Birmingham v Chelsea FC 05/09/1921 | View match | |
| Rotherham County v Coventry City FC 05/09/1921 | View match | |
| Leeds United FC v Bristol City FC 05/09/1921 | View match | |
| Arsenal FC v Preston North End FC 05/09/1921 | View match | |
| Fulham FC v Leicester City FC 05/09/1921 | View match | |
| Southampton FC v Luton Town FC 05/09/1921 | View match |