| South Shields AFC v Stoke 29/08/1921 | View match | |
| Merthyr Town v Reading FC 29/08/1921 | View match | |
| Partick Thistle FC v Aberdeen FC 30/08/1921 | View match | |
| Queens Park FC v Raith Rovers FC 31/08/1921 | View match | |
| Falkirk FC v Hibernian FC 31/08/1921 | View match | |
| Watford FC v Millwall FC 31/08/1921 | View match | |
| Gillingham FC v Charlton Athletic FC 31/08/1921 | View match | |
| Portsmouth FC v Bristol Rovers FC 31/08/1921 | View match | |
| Newcastle United FC v Everton FC 31/08/1921 | View match | |
| Sunderland FC v Burnley FC 31/08/1921 | View match | |
| Bury FC v Blackpool FC 31/08/1921 | View match | |
| Exeter City FC v Brighton & Hove Albion FC 31/08/1921 | View match |