| Port Vale FC v Burnley FC 16/12/1980 | View match | |
| Halifax Town A.F.C v Port Vale FC 20/12/1980 | View match | |
| Port Vale FC v Lincoln City FC 26/12/1980 | View match | |
| Northampton Town FC v Port Vale FC 27/12/1980 | View match | |
| Port Vale FC v Enfield 03/01/1981 | View match | |
| Enfield v Port Vale FC 06/01/1981 | View match | |
| Hartlepool United v Port Vale FC 10/01/1981 | View match | |
| Mansfield Town FC v Port Vale FC 24/01/1981 | View match | |
| Port Vale FC v Wimbledon 31/01/1981 | View match | |
| Aldershot F.C v Port Vale FC 07/02/1981 | View match | |
| Port Vale FC v Wigan Athletic FC 14/02/1981 | View match | |
| Port Vale FC v Bury FC 21/02/1981 | View match |