| Cheltenham Town FC v Plymouth Argyle FC 26/12/2021 | View match | |
| Birmingham City FC v Plymouth Argyle FC 08/01/2022 | £7.50 | |
| Sheffield Wednesday FC v Plymouth Argyle FC 15/01/2022 | £9.50 | |
| Plymouth Argyle FC v Lincoln City FC 22/01/2022 | £7.50 | |
| Fleetwood Town FC v Plymouth Argyle FC 25/01/2022 | View match | |
| Doncaster Rovers FC v Plymouth Argyle FC 29/01/2022 | View match | |
| Chelsea FC v Plymouth Argyle FC 05/02/2022 | £7.50 | |
| Crewe Alexandra FC v Plymouth Argyle FC 08/02/2022 | View match | |
| Plymouth Argyle FC v Shrewsbury Town FC 12/02/2022 | View match | |
| Gillingham FC v Plymouth Argyle FC 19/02/2022 | £7.50 | |
| Cambridge United FC v Plymouth Argyle FC 22/02/2022 | View match | |
| Plymouth Argyle FC v Rotherham United FC 26/02/2022 | View match |