| Newport County AFC v Plymouth Argyle FC 31/08/2021 | View match | |
| Plymouth Argyle FC v Sheffield Wednesday FC 11/09/2021 | £7.50 | |
| AFC Wimbledon FC v Plymouth Argyle FC 18/09/2021 | View match | |
| Portsmouth FC v Plymouth Argyle FC 21/09/2021 | View match | |
| Plymouth Argyle FC v Doncaster Rovers FC 25/09/2021 | £7.50 | |
| Plymouth Argyle FC v Crewe Alexandra FC 28/09/2021 | £7.50 | |
| Lincoln City FC v Plymouth Argyle FC 02/10/2021 | £7.50 | |
| Plymouth Argyle FC v Burton Albion FC 09/10/2021 | £7.50 | |
| Plymouth Argyle FC v Swindon Town FC 12/10/2021 | View match | |
| Oxford United FC v Plymouth Argyle FC 16/10/2021 | £8.50 | |
| Plymouth Argyle FC v Bolton Wanderers FC 19/10/2021 | View match | |
| Morecambe FC v Plymouth Argyle FC 23/10/2021 | £7.50 |