| Southampton FC v MK Dons (Milton Keynes Dons) 07/01/2006 | £4.50 | |
| Queens Park Rangers FC v Southampton FC 14/01/2006 | £4.00 | |
| Queens Park Rangers FC v Southampton FC 14/01/2006 | £5.00 | |
| Leicester City FC v Southampton FC 28/01/2006 | £4.80 | |
| Reading FC v Southampton FC 10/02/2006 | £6.50 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.00 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.50 | |
| Southampton FC v Preston North End FC 15/02/2006 | £4.50 | |
| Newcastle United FC v Southampton FC 18/02/2006 | £4.90 | |
| Southampton FC v Sheffield Wednesday FC 25/02/2006 | £3.00 | |
| Brighton & Hove Albion FC v Southampton FC 08/04/2006 | £5.50 | |
| Southampton FC v Plymouth Argyle FC 16/09/2006 | £3.00 |