| Southampton FC v Sheffield Wednesday FC 19/03/2011 | £3.50 | |
| Southampton FC v Leeds United FC 06/08/2011 | £8.50 | |
| Barnsley FC v Southampton FC 13/08/2011 | £12.00 | |
| Ipswich Town FC v Southampton FC 16/08/2011 | £5.50 | |
| Leicester City FC v Southampton FC 27/08/2011 | £6.50 | |
| Southampton FC v Birmingham City FC 18/09/2011 | £7.00 | |
| Southampton FC v Preston North End FC 21/09/2011 | £7.00 | |
| Burnley FC v Southampton FC 24/09/2011 | £5.50 | |
| Cardiff City FC v Southampton FC 28/09/2011 | £5.50 | |
| Southampton FC v Watford FC 01/10/2011 | £7.00 | |
| Southampton FC v West Ham United FC 18/10/2011 | £7.50 | |
| Crystal Palace FC v Southampton FC 25/10/2011 | £5.50 |