| Sparta Prague v Southampton FC 24/11/2016 | View match | |
| Southampton FC v Everton FC 27/11/2016 | £6.50 | |
| Arsenal FC v Southampton FC 30/11/2016 | £7.50 | |
| Crystal Palace FC v Southampton FC 03/12/2016 | £6.50 | |
| Southampton FC v Hapoel Beer - Sheva 08/12/2016 | £6.50 | |
| Southampton FC v Hapoel Beer - Sheva 08/12/2016 | £5.50 | |
| Southampton FC v Middlesbrough FC 11/12/2016 | View match | |
| Stoke City FC v Southampton FC 14/12/2016 | View match | |
| AFC Bournemouth v Southampton FC 18/12/2016 | View match | |
| Southampton FC v Tottenham Hotspur FC 28/12/2016 | £6.50 | |
| Southampton FC v Tottenham Hotspur FC 28/12/2016 | £5.50 | |
| Southampton FC v West Bromwich Albion FC 31/12/2016 | £6.50 |