| Chelsea FC v Derby County FC 12/11/1980 | £6.50 | |
| Reading FC v Gillingham FC 12/11/1980 | £3.00 | |
| Sunderland FC v Manchester City FC 12/11/1980 | £3.50 | |
| Fulham FC v Rotherham United FC 15/11/1980 | £3.50 | |
| Queens Park Rangers FC v Oldham Athletic FC 15/11/1980 | £2.50 | |
| Portsmouth FC v Barnsley FC 15/11/1980 | £4.50 | |
| Nottingham Forest FC v Tottenham Hotspur FC 15/11/1980 | £4.00 | |
| Blackburn Rovers FC v Cardiff City FC 15/11/1980 | £3.50 | |
| Wolverhampton Wanderers FC v Brighton & Hove Albion FC 15/11/1980 | £5.00 | |
| Wrexham FC v Chelsea FC 15/11/1980 | £4.50 | |
| Luton Town FC v West Ham United FC 15/11/1980 | £2.00 | |
| Southend United FC v Bury FC 15/11/1980 | £4.50 |