| Newport County v Aberdare Athletic 25/02/1922 | View match | |
| Walsall FC v Durham City 25/02/1922 | View match | |
| Hartlepool United v Crewe Alexandra FC 25/02/1922 | View match | |
| Grimsby Town FC v Wrexham FC 25/02/1922 | View match | |
| Port Vale FC v Crystal Palace FC 25/02/1922 | View match | |
| Stockport County FC v Nelson 25/02/1922 | View match | |
| Bury FC v Hull City FC 25/02/1922 | View match | |
| Barnsley FC v Bradford Park Avenue 25/02/1922 | View match | |
| Swansea Town v Southampton FC 25/02/1922 | View match | |
| Exeter City FC v Queens Park Rangers FC 25/02/1922 | View match | |
| Halifax Town A.F.C v Barrow 25/02/1922 | View match | |
| Rochdale FC v Ashington 25/02/1922 | View match |