| Watford FC v Southampton FC 22/10/1921 | View match | |
| Chesterfield FC v Nelson 22/10/1921 | View match | |
| Tranmere Rovers FC v Stalybridge Celtic 22/10/1921 | View match | |
| Gillingham FC v Southend United FC 22/10/1921 | View match | |
| Northern Ireland v England 22/10/1921 | View match | |
| Albion Rovers FC v Queens Park FC 22/10/1921 | View match | |
| Hamilton Academicals v Aberdeen FC 22/10/1921 | View match | |
| Dundee v Kilmarnock FC 22/10/1921 | View match | |
| Lochgelly United v Alloa Athletic FC 22/10/1921 | View match | |
| Clackmannan v Vale Of Leven 22/10/1921 | View match | |
| Accrington Stanley (1891) v Wrexham FC 22/10/1921 | View match | |
| Johnstone v Bathgate 22/10/1921 | View match |