| Aberdeen FC v Albion Rovers FC 30/04/1921 | View match | |
| Ayr United FC v Falkirk FC 30/04/1921 | View match | |
| Third Lanark v Clydebank FC (Old) 30/04/1921 | View match | |
| Raith Rovers FC v Rangers (Glasgow) FC 30/04/1921 | View match | |
| Motherwell FC v Kilmarnock FC 30/04/1921 | View match | |
| Airdrieonians (Old) v Celtic (Glasgow) FC 30/04/1921 | View match | |
| Merthyr Town v Brentford FC 30/04/1921 | View match | |
| South Shields AFC v Fulham FC 30/04/1921 | View match | |
| Clapton Orient v Notts County FC 30/04/1921 | View match | |
| Rotherham County v Birmingham 30/04/1921 | View match | |
| Bury FC v The Wednesday 30/04/1921 | View match | |
| Bristol City FC v Stoke 30/04/1921 | View match |