| Clyde v Airdrieonians (Old) 26/02/1921 | View match | |
| Aberdeen FC v Morton FC 26/02/1921 | View match | |
| St Mirren FC v Hibernian FC 26/02/1921 | View match | |
| Queens Park FC v Celtic (Glasgow) FC 26/02/1921 | View match | |
| Partick Thistle FC v Kilmarnock FC 26/02/1921 | View match | |
| Dundee v Raith Rovers FC 26/02/1921 | View match | |
| Hamilton Academicals v Falkirk FC 26/02/1921 | View match | |
| Merthyr Town v Luton Town FC 26/02/1921 | View match | |
| Dumbarton v Motherwell FC 26/02/1921 | View match | |
| Rotherham County v Leicester City FC 26/02/1921 | View match | |
| South Shields AFC v Notts County FC 26/02/1921 | View match | |
| Albion Rovers FC v Armadale 26/02/1921 | View match |