| West Ham United FC v Clapton Orient 22/01/1921 | View match | |
| Stoke v South Shields AFC 22/01/1921 | View match | |
| The Wednesday v Port Vale FC 22/01/1921 | View match | |
| Third Lanark v Hibernian FC 22/01/1921 | View match | |
| Queen Of The South FC v Blairgowrie Amaateurs 22/01/1921 | View match | |
| Arbroath FC v Kilmarnock FC 22/01/1921 | View match | |
| Alloa Athletic FC v Falkirk FC 22/01/1921 | View match | |
| Ayr United FC v Queens Park FC 22/01/1921 | View match | |
| Dundee v Inverness Caledonian 22/01/1921 | View match | |
| St Mirren FC v Armadale 22/01/1921 | View match | |
| Boness United v Galston 22/01/1921 | View match | |
| Clyde v Airdrieonians (Old) 22/01/1921 | View match |