| Preston North End FC v Birmingham City FC 12/09/1959 | View match | |
| Preston North End FC v Burnley FC 15/09/1959 | View match | |
| Tottenham Hotspur FC v Preston North End FC 19/09/1959 | View match | |
| Preston North End FC v Manchester United FC 26/09/1959 | View match | |
| Blackburn Rovers FC v Preston North End FC 03/10/1959 | £7.50 | |
| Preston North End FC v Dundee 06/10/1959 | View match | |
| Preston North End FC v Manchester City FC 10/10/1959 | £12.50 | |
| Arsenal FC v Preston North End FC 17/10/1959 | £10.50 | |
| Preston North End FC v Wolverhampton Wanderers FC 24/10/1959 | View match | |
| Blackpool FC v Preston North End FC 31/10/1959 | View match | |
| Preston North End FC v Nottingham Forest FC 07/11/1959 | View match | |
| Fulham FC v Preston North End FC 14/11/1959 | £5.50 |