| Morecambe FC v Plymouth Argyle FC 23/10/2021 | £7.50 | |
| Sheffield Wednesday FC v Plymouth Argyle FC 07/11/2021 | £10.50 | |
| Plymouth Argyle FC v Wycombe Wanderers FC 23/11/2021 | £7.50 | |
| Plymouth Argyle FC v Wigan Athletic FC 27/11/2021 | £7.50 | |
| Rochdale FC v Plymouth Argyle FC 05/12/2021 | £7.50 | |
| Sunderland FC v Plymouth Argyle FC 11/12/2021 | £7.50 | |
| Plymouth Argyle FC v Charlton Athletic FC 18/12/2021 | £7.50 | |
| Birmingham City FC v Plymouth Argyle FC 08/01/2022 | £7.50 | |
| Sheffield Wednesday FC v Plymouth Argyle FC 15/01/2022 | £9.50 | |
| Plymouth Argyle FC v Lincoln City FC 22/01/2022 | £7.50 | |
| Chelsea FC v Plymouth Argyle FC 05/02/2022 | £7.50 | |
| Gillingham FC v Plymouth Argyle FC 19/02/2022 | £7.50 |