| Morpeth Town A.F.C. v Buxton 22/01/2022 | View match | |
| Hyde United v Buxton 29/01/2022 | View match | |
| Buxton v South Shields AFC 05/02/2022 | View match | |
| Buxton v Basford United 08/02/2022 | View match | |
| Nantwich Town v Buxton 12/02/2022 | View match | |
| Buxton v Gainsborough 19/02/2022 | View match | |
| Atherton Collieries v Buxton 26/02/2022 | View match | |
| Bamber Bridge v Buxton 05/03/2022 | View match | |
| Buxton v Witton Albion 08/03/2022 | View match | |
| Buxton v Radcliffe Borough 12/03/2022 | View match | |
| Whitby Town v Buxton 19/03/2022 | View match | |
| Witton Albion v Buxton 26/03/2022 | View match |