| Reading FC v Barnsley FC 16/10/2021 | View match | |
| Middlesbrough FC v Barnsley FC 20/10/2021 | View match | |
| Barnsley FC v Sheffield United FC 24/10/2021 | View match | |
| Bristol City FC v Barnsley FC 30/10/2021 | View match | |
| Barnsley FC v Derby County FC 03/11/2021 | View match | |
| Barnsley FC v Hull City FC 06/11/2021 | View match | |
| Fulham FC v Barnsley FC 20/11/2021 | View match | |
| Barnsley FC v Swansea City FC 24/11/2021 | View match | |
| Peterborough United FC v Barnsley FC 27/11/2021 | View match | |
| Barnsley FC v Huddersfield Town FC 04/12/2021 | View match | |
| Preston North End FC v Barnsley FC 11/12/2021 | View match | |
| Barnsley FC v West Bromwich Albion FC 17/12/2021 | £7.50 |